Welcome to our comprehensive guide on critical limb ischemia treatment. Whether you are seeking information on critical limb ischemia regenerative therapy treatment in Delhi or critical limb ischemia regenerative therapy in Mumbai, you've come to the right place. Here, we provide detailed insights into symptoms, causes, risk factors, and modern treatment options for this serious condition. Our expertise, led by Dr. BS Rajput and his team at Cumballa Hill Hospital in Mumbai and Elantis Hospital in New Delhi, ensures you receive the best care possible.
Critical limb ischemia (CLI) is a severe arterial obstruction that reduces blood flow to the extremities, causing severe pain and ulcers or sores. It's a serious condition that necessitates prompt medical attention. Chronic critical limb ischemia can lead to gangrene and amputation if untreated.
CLI is a chronic condition, meaning it develops gradually over time. It's often a complication of Peripheral Arterial Disease (PAD), where fatty deposits (plaque) build up in the arteries, narrowing the passage for blood flow. This narrowing can eventually lead to complete blockage, causing critical limb ischemia.

Lower limb ischemia occurs when blood flow to the legs is restricted due to narrowed or blocked arteries. It represents a broader condition that includes both mild and severe stages of arterial obstruction. When this blockage progresses and causes tissue damage, it advances to critical limb ischemia (CLI) — the most serious stage of lower limb ischemia.
Lower limb ischemia cellular therapy treatment focuses on improving blood circulation and repairing damaged tissues through regenerative medicine. This approach uses the body’s own healing potential to restore oxygen supply to the affected area. Cellular therapy introduces healthy cells or growth factors directly into the ischemic limb to encourage new blood vessel formation (angiogenesis) and tissue recovery.
At Dr. B.S. Rajput’s Department of Orthopaedics and Advanced Orthobiologics, cellular therapy is used to support patients with both lower limb ischemia and critical limb ischemia. By combining advanced techniques such as bone marrow–derived cellular transplant, PRP (Platelet-Rich Plasma) therapy, and tissue grafting, the treatment aims to:
This minimally invasive therapy helps patients regain mobility, relieve pain, and improve limb function without extensive surgery. When started early, lower limb ischemia cellular therapy treatment can prevent disease advancement and reduce the risk of tissue loss.
| Feature | Lower Limb Ischemia | Critical Limb Ischemia (CLI) |
|---|---|---|
| Definition | Reduced blood flow to the legs due to arterial narrowing | Advanced stage of ischemia where tissue death risk is high |
| Severity | Mild to moderate | Severe and limb-threatening |
| Symptoms | Leg pain during walking (claudication), cold feet, weak pulse | Rest pain, non-healing ulcers, gangrene |
| Treatment Approach | Lifestyle modification, medication, and early cellular therapy | Urgent intervention including cellular therapy, angioplasty, or bypass surgery |
| Outcome | Often reversible if treated early | Requires immediate medical attention to prevent amputation |
Understanding the difference is important because early lower limb ischemia cellular therapy treatment can stop the progression before it becomes critical limb ischemia. Timely regenerative therapy helps preserve tissue health and maintain mobility.
CLI primarily affects individuals with a history of atherosclerosis or peripheral artery disease (PAD). It's more common in older adults, smokers, and those with diabetes, high cholesterol, or high blood pressure. Understanding critical limb ischemia causes is crucial for prevention and management.
Yes, CLI can be life-threatening. Without prompt critical limb ischemia intervention, the condition can lead to severe complications, including infections, tissue loss, and the potential need for amputation. Critical limb ischemia is a serious condition that can be life-threatening if left untreated. The lack of blood flow can lead to tissue death (gangrene) and infection, which can necessitate limb amputation and potentially spread to other parts of the body.
CLI is a relatively common condition, particularly among the elderly population. It's estimated that millions of people worldwide suffer from CLI, with a significant number residing in India.
CLI affects 1-2% of the population over the age of 50. It is more common in people who have diabetes as well as those with a history of heart problems. Early diagnosis and lower limb ischemia treatment are key to managing the condition effectively.
Below are some typical signs to look out for:
The primary cause of CLI is severe blockage in the arteries supplying blood to the legs. This blockage is usually caused by atherosclerosis, the buildup of plaque in the arteries. Other factors that can contribute to CLI include:
Diagnosis involves physical examination, ankle-brachial index (ABI) test, Doppler ultrasound, and imaging studies like angiography. Identifying critical limb ischemia classification helps determine the severity and appropriate treatment plan.
Risk factors for CLI include:
The best way to manage CLI is to prevent it altogether. Here are some preventive measures you can take:
Regular check-ups with a critical limb ischemia doctor in Delhi or critical limb ischemia doctor in Mumbai can help in early detection and prevention.
If you've been diagnosed with CLI, it's important to follow your doctor's treatment plan diligently. This may involve lifestyle modifications, medication, and potentially intervention procedures. Here's what you can expect:
Long-term management includes medications to improve blood flow, lifestyle modifications, and, in severe cases, surgical options like bypass surgery or angioplasty. The Department of Orthopaedics and Advanced Orthobiologics at our hospitals provides complete care, including innovative treatments like regenerative therapy and tissue transplant.
Dr. BS Rajput and his team of consultants at Cumballa Hill Hospital in Mumbai and Elantis Hospital in New Delhi specialize in advanced treatments. The Advanced Centre for Cellular Therapy in Orthopaedic and Neuromuscular Disorders provides cutting-edge treatments in regenerative medicine.
Fortunately, advanced treatment options are available for critical limb ischemia in both Delhi and Mumbai. Here at Dr. B.S. Rajput's Department of Orthopaedics and Advanced Orthobiologics, we offer a comprehensive approach to CLI management at Cumballa Hill Hospital in Mumbai and Elantis Hospital in New Delhi. Dr. Rajput and his team of consultants, Dr. Rajput and Associates, are renowned for their expertise in minimally invasive and regenerative treatments for CLI.
Our treatment philosophy focuses on maximizing blood flow restoration and promoting tissue regeneration in the affected limb. This frequently requires a mix of techniques, including:
If you're experiencing any symptoms suggestive of CLI, it's crucial to seek immediate medical attention. Early diagnosis and intervention are critical for successful treatment and preventing limb amputation. Please consult a doctor if you notice:
If you or a loved one is experiencing symptoms of CLI, don't wait. Contact Dr. Rajput and Associates at Cumballa Hill Hospital in Mumbai or Elantis Hospital in New Delhi for expert care. We offer comprehensive evaluations and personalized critical limb ischemia treatment in Delhi and Mumbai.
Cost of bone marrow derived cellular transplant in critical limb ischaemia is between 3 to 3.5 Indian Rupees lacs depending upon hospital and class of room.
Our team at Dr. B.S. Rajput's Department of Orthopaedics and Advanced Orthobiologics is dedicated to providing advanced treatment for critical limb ischemia. If you're in Delhi or Mumbai and experiencing symptoms of CLI, contact us today at +91-9820850187 to schedule an appointment. We offer minimally invasive, regenerative solutions tailored to your specific needs, aiming for optimal limb salvage and improved quality of life.
Take the first step towards better health and quality of life by making an appointment with our doctors today.